Rheumatic Diseases Task Force

Chairs: Johanna Paltta (FinnGen), Dawn Waterworth (J&J)

Main scientific questions

Aim 1: Genetic and Proteomic Determinants of Disease Course and Treatment Response to biologics

• Assess whether genetic and proteomic factors influence disease activity, progression, and response to biologic therapies in inflammatory rheumatic diseases, with a primary focus on Rheumatoid Arthritis (RA). Analyses will be extended to Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS), and systemic connective tissue diseases where sample size permits.

• Sub-aim: Evaluate the role of autoantibodies in disease progression and treatment response.

Aim 2: Shared Genetic Architecture Across Immune-Mediated Diseases

• Quantify pleiotropy between inflammatory immune-mediated diseases.

All Task Force related summary statistics can be found from: /finngen/library-green/task_force/

All Task Force GWASes can be found from Task Force PheWeb: https://results.taskforce.finngen.fi/

More detailed Scientific proposal, meeting materials and analysis documentation can be found in Teams here

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