# What’s new in DF11 endpoints

There were no systemic changes in Data Freeze (DF) 11's endpoints, only minor updates.

### DF11 legacy **samples**

New DF11 legacy **samples**, genotyped with the FinnGen array, were delivered from the following cohorts and biobanks:

* \~4700 The Finland-United States Investigation of NIDDM Genetics (FUSION) study subjects ([FUSION](https://thl.fi/en/web/thl-biobank/for-researchers/sample-collections/fusion-study), THL BB)
* \~3000 North Finland Birth Cohort study subjects born in 1986 ([NFBC 1986](https://www.oulu.fi/en/university/faculties-and-units/faculty-medicine/northern-finland-birth-cohorts-and-arctic-biobank), Arctic BB)
* \~1900 North Finland Birth Cohort study subjects born in 1966 ([NFBC 1966](https://www.oulu.fi/en/university/faculties-and-units/faculty-medicine/northern-finland-birth-cohorts-and-arctic-biobank), Arctic BB)
* \~1500 The diabetes register of the Vaasa hospital district study subjects ([DIREVA](https://www.vaasankeskussairaala.fi/globalassets/hallinnon-tiedostot/primarvardsenheten/direva---diabetesrekisteri/englanti/direva-info--suostumus-2018-engl.pdf), Auria BB)
* \~500 Northern Finland aging individuals ([Oulu 1935](https://www.oulu.fi/en/university/faculties-and-units/faculty-medicine/northern-finland-birth-cohorts-and-arctic-biobank), Arctic BB)
* \~650 Northern Finland aging individuals, ([Oulu 1945](https://www.oulu.fi/en/university/faculties-and-units/faculty-medicine/northern-finland-birth-cohorts-and-arctic-biobank), Arcitic BB)
* \~550 Finnish Health in Teens study subjects ([Fin-Hit](https://thl.fi/en/web/thl-biobank/for-researchers/sample-collections/fin-hit-study), THL BB)
* \~150 [Migrane](https://thl.fi/en/web/thl-biobank/for-researchers/sample-collections/migraine-study) study subjects (THL BB)
* \~30 [Finnish IPF](https://thl.fi/en/web/thl-biobank/for-researchers/sample-collections/finnish-ipf) study subjects (THL BB)

### New DF11 legacy genotypes

No new legacy samples **with previously generated genotypes from non-FinnGen arrays** were delivered to FinnGen for DF11.

All changes in the endpoints are described in the changelog file [here](https://www.finngen.fi/en/researchers/clinical-endpoints).

## Deleted endpoints

1 endpoint (custom endpoint, created for userresults)

* K11\_K03\_COMBINATION

## New endpoints

6 new endpoints

* DM2\_NEPHROPATHY
* DM2\_RETINOPATHY
* DM2\_NEUROPATHY
* DM1\_NEPHROPATHY
* DM1\_RETINOPATHY
* DM1\_NEUROPATHY

## Modified endpoints

336 modified endpoints

* 8 modified because typo in longname
* 10 endpoints with minor definition modifications
* 190 cancer control exclusions unified, now all EXALLC cancer endpoints have same exclusion rules
* Comorbidity and diabetes complication endpoints have now omit=2 (these endpoints won’t be released to Sandbox, Pheweb or Risteys)

See [changelog](https://www.finngen.fi/en/researchers/clinical-endpoints) for more details.


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