What’s new in DF11 endpoints

There were no systemic changes in Data Freeze (DF) 11's endpoints, only minor updates.

DF11 legacy samples

New DF11 legacy samples, genotyped with the FinnGen array, were delivered from the following cohorts and biobanks:

• ~4700 The Finland-United States Investigation of NIDDM Genetics (FUSION) study subjects (FUSION, THL BB)

• ~3000 North Finland Birth Cohort study subjects born in 1986 (NFBC 1986, Arctic BB)

• ~1900 North Finland Birth Cohort study subjects born in 1966 (NFBC 1966, Arctic BB)

• ~1500 The diabetes register of the Vaasa hospital district study subjects (DIREVA, Auria BB)

• ~500 Northern Finland aging individuals (Oulu 1935, Arctic BB)

• ~650 Northern Finland aging individuals, (Oulu 1945, Arcitic BB)

• ~550 Finnish Health in Teens study subjects (Fin-Hit, THL BB)

• ~150 Migrane study subjects (THL BB)

• ~30 Finnish IPF study subjects (THL BB)

New DF11 legacy genotypes

No new legacy samples with previously generated genotypes from non-FinnGen arrays were delivered to FinnGen for DF11.

All changes in the endpoints are described in the changelog file here.

Deleted endpoints

1 endpoint (custom endpoint, created for userresults)

• K11_K03_COMBINATION

New endpoints

6 new endpoints

• DM2_NEPHROPATHY

• DM2_RETINOPATHY

• DM2_NEUROPATHY

• DM1_NEPHROPATHY

• DM1_RETINOPATHY

• DM1_NEUROPATHY

Modified endpoints

336 modified endpoints

• 8 modified because typo in longname

• 10 endpoints with minor definition modifications

• 190 cancer control exclusions unified, now all EXALLC cancer endpoints have same exclusion rules

• Comorbidity and diabetes complication endpoints have now omit=2 (these endpoints won’t be released to Sandbox, Pheweb or Risteys)

See changelog for more details.