What's new in DF13 endpoints

There are some bigger gaterorical changes in DF13 endpoints:

• Cancer endpoints

• New rare diseases endpoints·

• Pruning of dental endpoints·

• Avohilmo added to especially infectious diseases endpoints

Cancer endpoints

Background: Previously cancer endpoints differed in both case and control definitions:

• Core endpoints, C3_XXX_EXALLC Renamed C3_XXX_WIDE

  • Definition:

    • Cases: Hilmo + Cancer registry

    • Controls: All cancers excluded

• Non-core endpoints, C3_XXX All cancers excluded from controls

  • Definitions:

    • Cases: Cancer registry

    • Controls: Cases excluded from controls

• Additional haematological cancers, e.g. C_LYMPHOMA Omitted

  • Definition:

    • Cases: Hilmo

    • Controls: Cases excluded from controls

Changes made for DF13:

• C3_XXX_EXALLC

  • Renamed as C3_XXX_WIDE

• C3_XXX

  • All cancers excluded from controls, name stays the same

• Additional haematological cancers, e.g. C_LYMPHOMA

  • Removed

• If _WIDE version couldn’t be created (no ICD-10 codes), _ExAlL versions removed and only normal version remained

As a summary, in DF13 all cancer endpoints have same control definition and differ only by case definitions, which will result two cancer endpoint categories: _WIDE with Hilmo included and original with only Cancer registry data.

New rare disease endpoints

• 106 new rare disease endpoints added

• Selection criteria

  • Case count > 30

Dental endpoint pruning

• Satu Strauz et al have gone through and curated all dental endpoints

• 3 new endpoint

  • Pulpitis

  • Necrosis of pulp

  • Periapical abscess

• 38 modified endpoints

  • Most are additions of avohilmo, change of control defintitions or name/longname changes

• 74 endpoints omitted (omit 1 or 2)

Wider infectious and congenital diseases endpoints (Primary health care codes [Avohilmo] added)

• Many infectious disease endpoints (AB1_XXX_WIDE)

• Many congenital disease endpoint (Q17_XXX_WIDE)

Additional smaller changes

• Renaming

  • G6_AD_WIDE renamed to AD_STRICT

    • Background:

      • G6_AD_WIDE was renamed as G6_NEURODEGENERATION in DF12

      • G6_AD_WIDE was redefined but redefinition resulted this being narrower than G6_ALZHEIMER

  • ESOSINOPHIL_DISEASE -> EOSINOPHIL_DISEASE

• New phenotypes

  • Lupus nephritis, neuromyelitis optica and membraneous nephropathy

  • Raynaud syndrome

  • Excessive earwax

  • Solid and liquid cancers

  • Wider kidney endpoints

    • All kidney diseases

    • Chronic kidney diseases wide

• Codes corrected or added to:

  • I9_NONISCHCARDMYOP_STRICT

  • AB1_CHOLERA

  • I9_HYPERTROCARDMYOP

  • I9_POSTAMI

  • H8_ACOUSNERVDIS

  • Avohilmo added to insomnia endpoint

• 3 medication endpoints had wrong ATC codes

  • THIAZOLINEDIONES

  • DPP4INH

  • GLP1ANA

• Added back as core endpoints

  • R18_MALAI_FATIG

  • I9_STR_SAH

  • T1D_WIDE (T1D omitted)