# What's new in DF13 endpoints

There are some bigger gaterorical changes in DF13 endpoints:

* Cancer endpoints
* New rare diseases endpoints·
* Pruning of dental endpoints·
* Avohilmo added to especially infectious diseases endpoints

**Cancer endpoints**

Background: Previously cancer endpoints differed in both case and control definitions:

* Core endpoints, C3\_XXX\_EXALLC **Renamed C3\_XXX\_WIDE**
  * Definition:
    * Cases: Hilmo + Cancer registry
    * Controls: All cancers excluded
* Non-core endpoints, C3\_XXX **All cancers excluded from controls**
  * Definitions:
    * Cases: Cancer registry
    * Controls: Cases excluded from controls
* Additional haematological cancers, e.g. C\_LYMPHOMA **Omitted**
  * Definition:
    * Cases: Hilmo
    * Controls: Cases excluded from controls

Changes made for DF13:

* C3\_XXX\_EXALLC
  * **Renamed as C3\_XXX\_WIDE**
* C3\_XXX
  * **All cancers excluded from controls, name stays the same**
* Additional haematological cancers, e.g. C\_LYMPHOMA
  * **Removed**
* If \_WIDE version couldn’t be created (no ICD-10 codes), \_ExAlL versions removed and only normal version remained

As a summary, in DF13 all cancer endpoints have same control definition and differ only by case definitions, which will result two cancer endpoint categories: \_WIDE with Hilmo included and original with only Cancer registry data.

**New rare disease endpoints**

* 106 new rare disease endpoints added
* Selection criteria
  * Case count > 30

**Dental endpoint pruning**

* Satu Strauz et al have gone through and curated all dental endpoints
* 3 new endpoint
  * Pulpitis
  * Necrosis of pulp
  * Periapical abscess
* 38 modified endpoints
  * Most are additions of avohilmo, change of control defintitions or name/longname changes
* 74 endpoints omitted (omit 1 or 2)

**Wider infectious and congenital diseases endpoints (Primary health care codes \[Avohilmo] added)**

* Many infectious disease endpoints (AB1\_XXX\_WIDE)
* Many congenital disease endpoint (Q17\_XXX\_WIDE)

**Additional smaller changes**

* Renaming
  * G6\_AD\_WIDE renamed to AD\_STRICT
    * Background:
      * G6\_AD\_WIDE was renamed as G6\_NEURODEGENERATION in DF12
      * G6\_AD\_WIDE was redefined but redefinition resulted this being narrower than G6\_ALZHEIMER
  * ESOSINOPHIL\_DISEASE -> EOSINOPHIL\_DISEASE
* New phenotypes
  * Lupus nephritis, neuromyelitis optica and membraneous nephropathy
  * Raynaud syndrome
  * Excessive earwax
  * Solid and liquid cancers
  * Wider kidney endpoints
    * All kidney diseases
    * Chronic kidney diseases wide
* Codes corrected or added to:
  * I9\_NONISCHCARDMYOP\_STRICT
  * AB1\_CHOLERA
  * I9\_HYPERTROCARDMYOP
  * I9\_POSTAMI
  * H8\_ACOUSNERVDIS
  * Avohilmo added to insomnia endpoint
* 3 medication endpoints had wrong ATC codes
  * THIAZOLINEDIONES
  * DPP4INH
  * GLP1ANA
* Added back as core endpoints
  * R18\_MALAI\_FATIG
  * I9\_STR\_SAH
  * T1D\_WIDE (T1D omitted)


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