# What’s new in DF9 endpoints

For DF8 we made systematic changes to reduce the number of redundant endpoints, for DF9 there were no such systematic changes, only minor updates.

### **General changes in DF9 endpoints:**

* New [truncated endpoint file for survival analysis](https://docs.finngen.fi/finngen-data-specifics/endpoints/complete-follow-up-time-of-the-finngen-registries-primary-endpoint-data/survival-analysis-using-the-truncated-endpoint-file-secondary-endpoint-data) done
  * In addition to “basic” endpoint file, Registry team provided [another endpoint](https://docs.finngen.fi/finngen-data-specifics/endpoints/complete-follow-up-time-of-the-finngen-registries-primary-endpoint-data/survival-analysis-using-the-truncated-endpoint-file-secondary-endpoint-data) file where all the register data has been cut by the end of 2019 and the follow-up end date is calculated based on the 31.12.2019 (end of death register, which is the earliest to end, this is the end to which all other registers will be cut). This file can be used for Survival analyses.
* New registry data included:
  * External causes of morbidity codes were previously omitted from Hilmo, now added to DF9 (ICD Chapter VWXY endpoints)
* New enriched registry data collections added:
  * Eastern Finland aneurysm collection (this increased not only the numbers in the aneurysm endpoints but also some I9 indirectly modified (INCLUDE/CONDITION) endpoints)
* 128 new endpoints reaching PheWeb for the first time due to exceeding the minimum of 80 cases needed
* Cancer registry behaviour code requirements added to in C3\_ and CD2\_INSITU endpoints (see below for more detailed description of the changes)

### **Deleted endpoints:**

* HERPLUS/NEG breast cancer endpoints deleted and re-named to ERPLUS/NEG
  * C3\_BREAST\_HERPLUS - C3\_BREAST\_ERPLUS
  * C3\_BREAST\_HERNEG - C3\_BREAST\_ERNEG
  * RX\_HERPLUS- RX\_ERPLUS
  * RX\_HERNEG - RX\_ERNEG
* C3\_LIP\_ORAL\_PHARYNX deleted and replaced with a wider C3\_HEAD\_AND\_NECK endpoint
* C3\_NSCLC was deleted as C3\_LUNG\_NONSMALL\_EXALLC captures the phenotype better

### **New endpoints:**

* New depression endpoints
  * F5\_DEPRESSION\_DYSTHYMIA
  * F5\_DEPRESSION\_RECURRENT
  * F5\_DEPRESSION\_PSYCHOTIC
* New classification into biologically more meaningful entities for some cancer endpoints (C3/CD2\_INSITU)
* New Ear-Nose-Throat endpoints
  * C3\_TONSIL\_BASETONGUE
  * CD2\_BENIGN\_SALIVARY\_KNOWN
  * F5\_SPECIFIC\_SPEECH
  * F5\_READING Z21\_SPEECH\_THERAPY

### **Modified endpoints - main concepts:**

* Cancer endpoints:
  * Requirement of a behaviour code 3 (BEH3, denoting malignant tumors) in the Finnish Cancer Registry diagnoses was added to all C3\_ cancer endpoints
  * Requirement of a behaviour code 2 (BEH2 meaning *in situ* lesions) in the Finnish Cancer Registry diagnoses was added to all CD2\_INSITU\_ endpoints
* VWXY endpoints (External causes of morbidity):
  * previously omitted from Hilmo, now added to DF9 - case counts increased
  * wrong control exclusion rules corrected
  * some longnames corrected to English
* GRAVES\_COND - incorrect operation codes were corrected
* I9\_VALVES - operation codes were updated. This also affects endpoints that include this code; I9\_VHD, I9\_OTHHEART, and RG\_OTHHEART