# What’s new in the DF10 endpoints There were no systemic changes in Data Freeze (DF) 10's endpoints, only minor updates. Altogether 2459 new endpoints reached the minimum of 50 cases, making them eligible for the core analysis team GWAS runs. ### DF10 legacy **samples** New DF10 legacy **samples**, genotyped with the FinnGen array, were delivered from the following cohorts and biobanks: * \~2700 Finnish Health in Teens study subjects (Fin-HIT, THL BB) * \~2350 male smokers (ATBC/SETTI study, THL BB) * \~440 back surgery patients from the Nordic Modic project (Nomod study, Eastern Finland BB) * \~950 normal pressure hydrocephalus patients, their relatives, and controls (Eastern Finland BB) * \~705 neurological disease patients, including Alzheimer disease patients (L-MCI study, Eastern Finland BB) * \~400 Kuopio Breast Cancer Project patients (KBCP, Eastern Finland BB) * \~170 migraine family patients (Migraine study, THL) * \~70 idiopathic intracranial hypertension patients (IIH cohort, Eastern Finland BB) * \~50 acute head injury patients (S100B biomarker study, Eastern Finland BB) ### New DF10 legacy genotypes New DF10 legacy **genotypes,** genotyped with various Illumina arrays, were delivered from the following cohorts and biobanks: * \~4800 North Finland Birth Cohort study subjects born in 1966 (NFBC 1966, Arctic BB) * \~3500 North Finland Birth Cohort study subjects born in 1986 (NFBC 1986, Arctic BB) \ All changes in the endpoints are additionally described in the changelog file[ here](https://www.finngen.fi/en/researchers/clinical-endpoints). ### Deleted endpoints 50 endpoints were deleted: * 18 deleted for renaming purposes; removed \_INCLAVO from short name * 11 deleted due to other renaming purposes * 14 redundant endpoints deleted * 5 placeholder, 1 helper, and 1 too-broadly defined endpoint deleted. * In addition, comorbidity and diabetes complication endpoints have now omit=2 (these endpoints won’t be released to Sandbox, Pheweb or Risteys) ### ### ### New endpoints 32 new endpoints were added: * 2 new core endpoints * G6\_RLS * AB1\_LYME * 1 new non-core endpoint * K11\_K03\_COMBINATION * 29 new endpoints because of renaming * 18 \_INCLAVO endings removed from the endpoints' short names * 11 endpoints renamed because of spelling errors or illogical naming. ### Modified endpoints 81 endpoints were modified: * 38 had an #AVO tag added * 9 had an #ICDMAIN tag added * 7 “special” columns were cleared as markings have become outdated * 5 endpoints' long names or included names were changed * 21 endpoint definitions were improved * CD2\_NONHODGKIN\_NAS had its control definition corrected. See the [changelog](https://www.finngen.fi/en/researchers/clinical-endpoints) for more details. --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://docs.finngen.fi/finngen-data-specifics/endpoints/where-the-finngen-endpoint-description-file-is-located/whats-new-in-the-df10-endpoints.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.