Imputation Panel

History of the SiSu Project

The International Sequencing Initiative Suomi (SISu) Project was launched in 2011 to collect and facilitate a wider usage of Finnish whole-genome sequencing (WGS) and whole-exome sequencing (WES) datasets.

For the longest time, Finnish (and Finnophile) geneticists have been using SISu as a resource for referring to Finnish specific allele frequencies and understanding Finnish genetic architecture.

How do we use the SiSu imputation panel?

The convenience of using FinnGen data is that the genotype data is imputed against a Finnish specific (Sisu) imputation panel.

The Sisu imputation panels used are described in the subsections of both

• Sisu v4 (as of August 2021) and

• Sisu v3 (as of FinnGen R2) reference panel sections