after an upgrade, you will need to shut down and reopen your Sandbox. If you don't restart after an upgrade sometimes unexpected behaviors can occur.
It is always safer to shut down your IVM before an upgrade.
How to shut it down
You can shut down your IVM from 3 places indicated on the diagram:
from the button located on the desktop
from the sidebar opening from arrowhead (>) at left
from top-right drop-down menu
Forcing a shutdown
If your IVM is unresponsive you may have exceeded the memory limit in your Sandbox. To force IVM to shut down see if the start button in the left sidebar (step 2 in the above figure) is available and click it.