# Risteys

[Risteys](https://risteys.finngen.fi) is a useful web portal for understanding FinnGen [endpoints](/finngen-data-specifics/endpoints/finngen-clinical-endpoints.md) and [laboratory measurement](/finngen-data-specifics/red-library-data-individual-level-data/what-phenotype-files-are-available-in-sandbox-1/kanta-lab-values.md) data. Risteys contains data from both [FinRegistry](https://www.finregistry.fi) and [FinnGen](https://www.finngen.fi/en), making it easy to compare the data from both sources side-by-side.

Whereas FinnGen is enriched for diseases and contains **10% of the Finnish population**, which is [**genotyped**](/background-reading/imputation.md), FinRegistry was a research project with a population sample of **\~7 million individuals** (everone alive in 2010 and their parents) with highly similar phenotype data to FinnGen but **no genotype data**.

|             | Number of individuals | Register data                                                                    | Genetic data         | Enrichment                                                                     | Organization             |
| ----------- | --------------------- | -------------------------------------------------------------------------------- | -------------------- | ------------------------------------------------------------------------------ | ------------------------ |
| FinnGen     | 520,210               | Hospital, prescription, KELA reimbursements, primary care + specialty registries | Yes, all individuals | Selected for individuals with medical conditions (clinics, legacy collections) | FinnGen Consortium       |
| FinRegistry | \~7 million           | Same as FinnGen + additional registries such ICUs                                | No                   | General population                                                             | Andrea Ganna's lab & THL |

Risteys is available to everyone at <https://risteys.finngen.fi/> (*no credentials or registration needed*).

A [tutorial](https://risteys.finngen.fi/documentation#tutorial), [how-to section](https://risteys.finngen.fi/documentation#how-to), [explanations](https://risteys.finngen.fi/documentation#explanations), and [methods](https://risteys.finngen.fi/documentation#methods) are found on Risteys website in the [documentation page](https://risteys.finngen.fi/documentation).

If you'd like to see more, please watch these demo videos

* [Risteys FinnGen endpoint browser demo at FinnGen Users' Meeting on 28th of November 2023](https://vimeo.com/user18033117)
* [Rresentation of New FinnGen tools and their application to example diseases from User's meeting 28th March 2023 recording ](https://www.finngen.fi/en/members/recordings/finngen-data-users-meeting-28th-march-2023)(at 25min 23sec) including usage of Risteys.
* Risteys Release 8 update in [FinnGen Data Users' meeting on 14th December 2021](https://www.finngen.fi/en/members/recordings/finngen-users-meeting-14th-december-2021)
* New endpoint explainer in Risteys in [FinnGen Data Users' meeting on 26th January 2021](https://www.finngen.fi/en/members/recordings/finngen-data-users-meeting-26-jan-2021)
* [Risteys tutorial](https://vimeo.com/402146003) (R4, March 2020)

See also frequently asked questions about [Risteys](/faq/about-risteys.md).

On Risteys, you can look up any FinnGen endpoint and obtain:

* **Endpoint Definition** (e.g. *which ICD-10 codes make up the endpoint*)

<div data-full-width="false"><figure><img src="/files/7ld8DXZaCE9ZaCn0D3ol" alt=""><figcaption></figcaption></figure></div>

* **Upset plot detailing case counts by codes** (*opening from the link on the lower right corner near the Endpoint Definition box)*

<figure><img src="/files/aGHUFBfVpX1lJRFJdsMb" alt=""><figcaption></figcaption></figure>

* **Table of case counts by codes** (*opening from the link on the lower right corner near the Endpoint Definition box)*

<figure><img src="/files/FRo9mWUpeQA6L3PhV0Xy" alt=""><figcaption></figcaption></figure>

* **Summary phenotype statistics for the endpoint in both FinnGen data and FinRegistry data** (e.g. *number of cases, age at first event*)

<figure><img src="/files/7idSUHDfZ9uOFTl18TS3" alt=""><figcaption></figcaption></figure>

<figure><img src="/files/rwhbgHP0vMImkghNz3kh" alt=""><figcaption></figcaption></figure>

* **Similar endpoints** on Risteys: In addition, it is possible to navigate endpoints by a subset or superset of cases for the current endpoint.

<figure><img src="/files/IOyBvfsmI84ZypMs3o6d" alt=""><figcaption></figcaption></figure>

Risteys also has a section showing the **association between an exposure endpoint and death (FinRegistry data)** and a **Relationships between endpoints** section presenting **survival analysis results from FinRegistry and genetic analyses results from FinnGen**.

<figure><img src="/files/VXVeJxn5CWenl6B566B8" alt=""><figcaption><p>You can press the "?" -button in Risteys to get more information about these sections</p></figcaption></figure>

<figure><img src="/files/UjuOIJz4auhHlidOB0Uu" alt=""><figcaption></figcaption></figure>

On top of the page, Risteys provides links to the [Endpoint Browser](/working-outside-the-sandbox/endpoint-browser.md) and [PheWeb](/working-outside-the-sandbox/link-to-how-to-use-pheweb.md) pages of the endpoint opened in Risteys. The [Endpoint Browser](/working-outside-the-sandbox/endpoint-browser.md) is a tool to visualize hierarchy and relatedness between similar endpoints. The [PheWeb](/working-outside-the-sandbox/link-to-how-to-use-pheweb.md) provides GWAS results for the endpoint.

<figure><img src="/files/-MhYMWBgQbtkVpWrop64" alt=""><figcaption></figcaption></figure>

**Risteys of previous data releases can be found under the arrow menu (see below):**

<figure><img src="/files/XlN6xLVSSe5Y4hpFgCvU" alt=""><figcaption></figcaption></figure>


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# Agent Instructions: Querying This Documentation

If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.

Perform an HTTP GET request on the current page URL with the `ask` query parameter:

```
GET https://docs.finngen.fi/working-outside-the-sandbox/risteys-as-an-option-for-browsing-endpoints.md?ask=<question>
```

The question should be specific, self-contained, and written in natural language.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.

Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.