# Risteys

[Risteys](https://risteys.finngen.fi) is a useful web portal for understanding FinnGen [endpoints](../finngen-data-specifics/endpoints/finngen-clinical-endpoints). Risteys contains data from both [FinRegistry](https://www.finregistry.fi) and [FinnGen](https://www.finngen.fi/en), making it easy to compare the data from both sources side-by-side.

Whereas FinnGen is enriched for diseases and contains **10% of the Finnish population**, which is [**genotyped**](../background-reading/imputation), FinRegistry is a population sample with **\~7 million individuals** with highly similar phenotype data to FinnGen but **no genotype data**.

<figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-a4782ca8dbaa5fe536f4c5b51044617f564919d7%2Fristeys_6.1.png?alt=media" alt=""><figcaption></figcaption></figure>

Risteys is available to everyone at [https://risteys.finregistry.fi](https://risteys.finregistry.fi) (_no credentials or registration needed_).

A [tutorial](https://risteys.finngen.fi/documentation#tutorial), [how-to section](https://risteys.finngen.fi/documentation#how-to), [explanations](https://risteys.finngen.fi/documentation#explanations), and [methods](https://risteys.finngen.fi/documentation#methods) are found on Risteys website in the [documentation page](https://risteys.finngen.fi/documentation).&#x20;

If you'd like to see more, please watch these demo videos

* [Risteys FinnGen endpoint browser demo at FinnGen Users' Meeting on 28th of November 2023](https://vimeo.com/user18033117)
* P[resentation of New FinnGen tools and their application to example diseases from User's meeting 28th March 2023 recording ](https://www.finngen.fi/en/members/recordings/finngen-data-users-meeting-28th-march-2023)(at 25min 23sec) including usage of Risteys.
* Risteys Release 8 update in [FinnGen Data Users' meeting on 14th December 2021](https://www.finngen.fi/en/members/recordings/finngen-users-meeting-14th-december-2021)
* New endpoint explainer in Risteys in [FinnGen Data Users' meeting on 26th January 2021](https://www.finngen.fi/en/members/recordings/finngen-data-users-meeting-26-jan-2021)
* [Risteys tutorial](https://vimeo.com/402146003) (R4, March 2020)

See also frequently asked questions about [Risteys](../faq/about-risteys).



On Risteys you can look up any FinnGen endpoint and obtain:

* **Endpoint Definition** (e.g. _which ICD-10 codes make up the endpoint_)

<div data-full-width="false"><figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-789ea582ccbb3315dbc5c7b5d912775b33baabcb%2Fristeys_1.png?alt=media" alt=""><figcaption></figcaption></figure></div>

* **Upset plot detailing case counts by codes** (_opening from the link on the lower right corner near the Endpoint Definition box)_

<figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-9e5e6e7e8a4188128565ab2055acbbed02e0fe4e%2Fristeys_2.png?alt=media" alt=""><figcaption></figcaption></figure>

* **Table of case counts by codes** (_opening from the link on the lower right corner near the Endpoint Definition box)_

<figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-42fe03784a75f8f10481506cafb975d39d5952ca%2Fristeys_3.png?alt=media" alt=""><figcaption></figcaption></figure>

* **Summary phenotype statistics for the endpoint in both FinnGen data and FinRegistry data** (e.g. _number of cases, age at first event_)

<figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-57cb3ac5cb65db4863c4893d9ff05b86e23f3b01%2Freisteys_4.png?alt=media" alt=""><figcaption></figcaption></figure>

<figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-9f573a6ede1aa50b91320886dcea8d053d3bc335%2Fristeys_5.1.png?alt=media" alt=""><figcaption></figcaption></figure>

* **Similar endpoints** on Risteys: In addition, it is possible to navigate endpoints by a subset or superset of cases for the current endpoint.

<figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-967329d06e892bf8557cacd51cae8d4c3b084511%2Fimage%20(96).png?alt=media" alt=""><figcaption></figcaption></figure>

Risteys also has a section showing the **association between an exposure endpoint and death (FinRegistry data)** and a **Relationships between endpoints** section presenting **survival analysis results from FinRegistry and genetic analyses results from FinnGen**.

<figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-8736cc12e601648811651390500dfd2038a00019%2Fristeys_7.png?alt=media" alt=""><figcaption><p>You can press the "?" -button in Risteys to get more information about these sections</p></figcaption></figure>

<figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-61cdc222c5b37a2fabb68601f0d8931f4112c0e0%2Fristeys_8.png?alt=media" alt=""><figcaption></figcaption></figure>

On top of the page, Risteys provides links to the [Endpoint Browser](endpoint-browser) and [PheWeb](link-to-how-to-use-pheweb) pages of the endpoint opened in Risteys. The [Endpoint Browser](endpoint-browser) is a tool to visualize hierarchy and relatedness between similar endpoints. The [PheWeb](link-to-how-to-use-pheweb) provides GWAS results for the endpoint..

<figure><img src="https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-60507d2a278cc2eb4a917e1c5719b9c8531d8b8a%2Fimage%20(63).png?alt=media" alt=""><figcaption></figcaption></figure>

**Risteys of previous data releases can be found here:**

[https://r11.risteys.finregistry.fi/](https://r10.risteys.finregistry.fi/)

[https://r10.risteys.finregistry.fi/](https://r10.risteys.finregistry.fi/) (first version with FinnGen and FinRegistry data)

[https://r10.risteys.finngen.fi/](https://r10.risteys.finngen.fi/)

[https://r9.risteys.finngen.fi/](https://r9.risteys.finngen.fi/)

[https://r8.risteys.finngen.fi/](https://r8.risteys.finngen.fi/)

[https://r7.risteys.finngen.fi/](https://r7.risteys.finngen.fi/)

[https://r6.risteys.finngen.fi/](https://r6.risteys.finngen.fi/)

[https://r5.risteys.finngen.fi/](https://r5.risteys.finngen.fi/)

[https://r4.risteys.finngen.fi/](https://r4.risteys.finngen.fi/)

[https://r3.risteys.finngen.fi/](https://r3.risteys.finngen.fi/)
