# GWAS Association to Biological Function

Understanding how to take a GWAS association to a biological understanding can be a complex process. To most of us, this tends to be a bit more of a combination of crafting instincts from available facts than a science.

Now that you have potentially identified a handful of variants of interest (Figure below), what do you do now? You may have to then run additional experiments and fine tune your variant to a gene or biological function. [Eddie from Gosia Tryka's group wrote a wonderful review](https://www.frontiersin.org/articles/10.3389/fgene.2020.00424/full) where the figure below is adapted from.

![Adapted from Cano-Gamez and Gosia Trynka (2020) Frontiers in Genetics](https://3072695768-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F-MhYL0UTLjqsuIdK0SSO%2Fuploads%2Fgit-blob-e7c7a77ef7e510167207ca033f7e7f16bd33babb%2Fimage%20\(108\).png?alt=media)

One of our FinnGen partners, [Eric Fauman](https://twitter.com/eric_fauman?lang=en), has [Tweetorials](https://twitter.com/Eric_Fauman/status/1659633257166565376) on frequent examples of how you might explore which is the causal gene from a GWAS. We encourage you to check it out for some examples.

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